It really depends on the year, model, engine, tranny...they have all had their lemmons.
I personally love a Dodge. They are the ones I have had the best luck with. Our '06 3500 has been through Hell and back, still going strong. My old 94 2500 I sold to the ranch when we left it has over 300K hard miles on it. Snow and mud for 6 months out of the year. Dirt roads and not many highway miles pulling a loaded stock trailer.
I always post this pic, but I will put it up again....ol red...