I am blind in one eye, and I do jumpers with my horse. I must admit that I do have trouble seeing the distance to the jump, but my horse is very willing and I feel when to get in 2-point. I have been blind in one eye since birth, and it never really affected me, as my body has adjusted. My old instructor use to have us count, 3,2,1, jump. I could never do that as I could not see how far the jump is.
As for driving, I do drive and the only time I notice a difference is when the light turns yellow, as I am unaware as to whether I should stop or go, as I cannot compare how much ground there is to the light. When driving behind cars, I just look at how much road there is between me and the car.