HYPP n/n?
   

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HYPP n/n?

This is a discussion on HYPP n/n? within the Horse Breeding forums, part of the Horse Breeds, Breeding, and Genetics category
  • Hypp n/n can it be passed on?
  • How to read a hypp nn result

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    08-26-2012, 10:50 AM
  #1
bjb
Weanling
HYPP n/n?

So does hypp n/n mean the horse is not a carrier of the disease Hyperkalemic Periodic Paralysis and is safe to breed to or can they still pass the disease on to offspring? From how I understand it, that means the horse is safe and can't pass the HYPP on but a family member says they still can have offspring with with it...... whats the truth?
     
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    08-26-2012, 11:38 AM
  #2
Trained
If a horses is N/N for HYPP the ONLY way for their offspring to have HYPP is if the horse they are bred to is positive to HYPP. HYPP N/N horses have ZERO copies of they HYPP gene to pass on.
     
    08-26-2012, 02:33 PM
  #3
Foal
Hypp

N/N means he is negative for the gene

N/H means he is positive on one side and would be a 50% chance passed if the mare was also N/H. But a 25% chance if mare is not a carrier.

H/H is positive on both side and there is a 50/50 chance of passing the gene. A 75% if the mare is N/H and 100% chance if the mare is H/H
     
    08-26-2012, 02:42 PM
  #4
Green Broke
Yep as the above posters pointed out...find another horse to breed to that is also N/N and you'll have nothing to worry about in the way of HYPP
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    08-27-2012, 10:01 AM
  #5
Weanling
Quote:
N/N means he is negative for the gene

N/H means he is positive on one side and would be a 50% chance passed if the mare was also N/H. But a 25% chance if mare is not a carrier.

H/H is positive on both side and there is a 50/50 chance of passing the gene. A 75% if the mare is N/H and 100% chance if the mare is H/H
Forgive me, but I don't think that's right. Yes, an n/n horse does not have the HYPP gene, but those percentages seem off.

An HYPP n/n horse has no coppies of the HYPP gene. It is simply not there and they will never pass it on to their offspring. The N stands for negative, I believe. If you tested an Arabian for HYPP, they would be n/n. That does not imply that the horse has any connection at all with the disease.

If a horse is n/H, they have one copy of HYPP. If they are H/H they have two copies. An n/H horse always has a 50% chance of passing on one copy of HYPP and producing a positive foal. An H/H horse has a 100% chance of passing on one copy of the gene and producing a positive foal.

So if you bred an n/n to an n/H, 50% of the foals will be n/H. If you bred an n/n with an H/H, 100% of the foals will be n/H. If you bred an n/H to an H/H, 50% of the foals would be n/H and 50% of the foals would be H/H. If you bred an H/H to an H/H, 100% of the foals would be H/H.
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    08-27-2012, 10:12 AM
  #6
Started
Breeding an affected heterozygous horse (N/H) to an affected heterozygous horse (N/H) will result in approximately 50% carrying the defective gene (N/H), approximately 25% will be normal (N/N) and approximately 25% will be homozygous carriers (H/H). Breeding an affected heterozygous horse (N/H) to a normal horse (N/N) will result in approximately 50% normal offspring and approximately 50% carrying the defective gene (N/H).
     
    08-27-2012, 10:16 AM
  #7
Weanling
Oops. I accidentally left the n/H x n/H cross out! Thanks for catching that. I need more coffee, clearly. :P
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    08-27-2012, 11:46 AM
  #8
Foal
Quote:
Originally Posted by WalnutPixie    
Oops. I accidentally left the n/H x n/H cross out! Thanks for catching that. I need more coffee, clearly. :P
this is the way my vet broke it down for me. Because I had an hypp stud positive on one side and I wanted to know a foals chances when breeding to my paint mare who does not carry the gene at all. But if I am wrong ok..but this is how my vet broke it down to ne and wrote it out..i just copied what I was told. Either way her question was about a negative horse which means there is no posibility of passing the gene on. Good luck with your horse.
Heather
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    08-28-2012, 10:22 AM
  #9
bjb
Weanling
Well thanks guys! That's exactly how I thought it worked too. But for some reason the family member I was speaking of said he knew someone who "supposedly" bred two hypp tested horses with n/n and they produced a n/h foal... I personally think something about that story can't possibly be right but he swears by it and refuses to buy or breed to ANY horse with impressive in the bloodlines anywhere regardless of how far back or testing results. I think I would be comfortable with it so long as the results are n/n and I would never buy one without testing


P.s. ...... these are also people who believe things like a horse with blue eyes are crazy and other such nonsence
     
    08-28-2012, 11:32 AM
  #10
Foal
Quote:
Originally Posted by bjb    
well thanks guys! That's exactly how I thought it worked too. But for some reason the family member I was speaking of said he knew someone who "supposedly" bred two hypp tested horses with n/n and they produced a n/h foal... I personally think something about that story can't possibly be right but he swears by it and refuses to buy or breed to ANY horse with impressive in the bloodlines anywhere regardless of how far back or testing results. I think I would be comfortable with it so long as the results are n/n and I would never buy one without testing


P.s. ...... these are also people who believe things like a horse with blue eyes are crazy and other such nonsence
I LOVE those kind of people...i think you are pretty reasonable in asking an "outside" source...lol... good luck with future babies!
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