Maintaining pregnancy with Regumate - The Horse Forum
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post #1 of 20 Old 05-23-2011, 02:39 PM Thread Starter
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Maintaining pregnancy with Regumate

All I can find on google is how to do it in normal sized horses but nothing about draft horses.

Caleigh was put on regumate to maintain her pregnancy since she's never been AI'd before and the vet said if I wanted to use it he would dose her.
Today was her 32 day ultrasound and she had slipped the baby, even on regumate. So we're starting over again on Thursday.
I called the collecting guy and told him and he said he was sorry to hear that and he'll do what he can to get me a discount on the next shipment over to me. He also said "draft horses and regumate do not go together" but he didn't elaborate on it. I called my vet and left a message asking if he knew anything about this and I called another vet just out of curiosity to find out if they've heard anything like this.

Before this pregnancy she was pasture bred for her last 3 and had no regumate. So maybe this time around even though it's AI I should leave her off of it? I don't know. I haven't heard anything about it before?

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post #2 of 20 Old 05-23-2011, 03:42 PM
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Did you check her progesterone level? If so where was it at? Was it low and if so how low.

I use Regu Mate on some of my mares however I keep an eye on levels. If it is not needed I do not use it.

Also if you do use it was it the correct dosage. A Draft if a lot larger then a stock mare so the dose would be much higher.

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post #3 of 20 Old 05-23-2011, 03:45 PM Thread Starter
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I'll have to check the papers. I told him to do everything he needed to do to maintain this pregnancy so he put her on 14cc of regumate every morning. Not sure if he checked her levels but she was positive and on it at her 16 day check. She stayed on it until today and now she's not pregnant so we pulled her off of it.
She's never been on it before from what I've been told but she was pasture bred for all her previous pregnancies. This isn't an option though since the stud is in Montana and I'm in Washington State. AI is my only option.

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post #4 of 20 Old 05-23-2011, 03:49 PM
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There could be many many reasons why she slipped and non of then could be low progesterone. That is normally why you would use regu mate. I use it for that as needed. I also use it to time breeding. Which is actually what it is meant for.

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post #5 of 20 Old 05-23-2011, 03:53 PM Thread Starter
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I think they started her on day 6 with it. I'm not sure why she slipped and neither is the vet. I'm thinking since it was only her second heat maybe she wasn't ready to carry yet. I just really hope it doesn't happen again but I don't know how to manage it.

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post #6 of 20 Old 05-26-2011, 12:38 AM
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Regumate is highly overused and overprescribed. It is seen as a panacea for any reproductive problem that results in a mare not carrying a pregnancy to term. For more information on it's use, check out this article on our website:

Does My Mare Need Regumate?

Hope this helps!

Kathy St.Martin
Equine-Reproduction.com, LLC
Equine Reproduction

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post #7 of 20 Old 05-26-2011, 01:54 AM Thread Starter
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Thank you, I'll take a look. Right now the plan is to breed, do blood work at 30, 45, and 55 and then decide.

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Last edited by drafts4ever; 05-26-2011 at 01:58 AM.
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post #8 of 20 Old 05-29-2011, 03:09 AM
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Deciding after 55 days of confirmed pregnancy would be too late to save the fetus, if indeed the mare was going to slip it due to low progesterone. If your mare is confirmed pregnant at 14 days, then I would get her blood work done to see where her progesterone levels are at. Your vet can prescribe you on what to do from there with your own individual mare....but with our mare last year, she slipped her pregnancy at 30 days (which is right when they would slip if they have low progesterone. The CL on her ovary supplies the mare with enough progesterone they need to maintain pregnancy up until 30 days. If their bodies aren't producing enough on their own after that day, then bye bye baby.) On the mare's next successful breeding we had to give the mare 10 cc of Regumate every day (starting at 20 days) until she was 150 days along (or was it 100? I can't remember. lol) Then we pulled her off it and she is currently about to foal in the next couple days.

Good luck with your next breeding! I hope your mare takes for you!

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post #9 of 20 Old 05-29-2011, 06:53 AM
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Quote:
Originally Posted by Juna View Post
Deciding after 55 days of confirmed pregnancy would be too late to save the fetus, if indeed the mare was going to slip it due to low progesterone.
You are correct on that.

Quote:
If your mare is confirmed pregnant at 14 days, then I would get her blood work done to see where her progesterone levels are at. Your vet can prescribe you on what to do from there with your own individual mare....but with our mare last year, she slipped her pregnancy at 30 days (which is right when they would slip if they have low progesterone. The CL on her ovary supplies the mare with enough progesterone they need to maintain pregnancy up until 30 days.
By fourteen days post ovulation, if the mare is pregnant chances are very good you do not need progesterone supplementation. But, the original ovulation and resultant CL are NOT sufficient to maintain a pregnancy through 30 days. The mare should be developing and having secondary CL's by that point. Think about it. If the mare is not pregnant, the original CL is resolving by around day 14 and by day 16 to 18, if there is no pregnancy, she is returning to estrus. If the mare needs supplementation, it should be initiated by no later than day 4 or 5 post ovulation to be effective if indeed the mare is truly a candidate for supplementation. Additionally, if you "are" going to supplement, use Altrenogest (Regumate or the injectable form from BET Pharm) as you can still test the mare and determine HER progesterone levels. It doesn't interfere with test results.

Quote:
If their bodies aren't producing enough on their own after that day, then bye bye baby.) On the mare's next successful breeding we had to give the mare 10 cc of Regumate every day (starting at 20 days) until she was 150 days along (or was it 100? I can't remember. lol) Then we pulled her off it and she is currently about to foal in the next couple days.
120 to 150 days is correct. But, if your mare is pregnant at 20 days without supplementation, chances are she is fine on her progesterone levels. By 120 to 150 days the feto-placental unit is responsible for the production of progestins.

Hope that helps!

Kathy St.Martin
Avalon Equine
Welcome to Avalon Equine ~ Quality Performance Sport Horses

and

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post #10 of 20 Old 05-29-2011, 12:15 PM
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Quote:
By fourteen days post ovulation, if the mare is pregnant chances are very good you do not need progesterone supplementation. But, the original ovulation and resultant CL are NOT sufficient to maintain a pregnancy through 30 days. The mare should be developing and having secondary CL's by that point. Think about it. If the mare is not pregnant, the original CL is resolving by around day 14 and by day 16 to 18, if there is no pregnancy, she is returning to estrus. If the mare needs supplementation, it should be initiated by no later than day 4 or 5 post ovulation to be effective if indeed the mare is truly a candidate for supplementation. Additionally, if you "are" going to supplement, use Altrenogest (Regumate or the injectable form from BET Pharm) as you can still test the mare and determine HER progesterone levels. It doesn't interfere with test results.
Ahh, that's good to know. I'm not sure if my vet has his facts mixed up or what, but what I described is what we did with our mare. And my vet's instructions made sense to me because our mare kept slipping her pregnancy at 30 days. (it happened twice, two years running. The first time, it was too late in the year to breed her again. The second year she slipped once before we had her levels tested at the second 14 days confirmed pregnancy, per vet instruction. That's when we found out her levels were extremely low. We started Regumate and she held on to the fetus through to term.)

Quote:
120 to 150 days is correct. But, if your mare is pregnant at 20 days without supplementation, chances are she is fine on her progesterone levels. By 120 to 150 days the feto-placental unit is responsible for the production of progestins.

Hope that helps!
That does help a lot, Avalon. I'll have a chat with my vet and see if maybe I misunderstood his reasoning on why we did what we did with our mare. Thanks!

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