Lethal white syndrome
 
 

       The Horse Forum > Horse Breeds, Breeding, and Genetics > Horse Colors and Genetics

Lethal white syndrome

This is a discussion on Lethal white syndrome within the Horse Colors and Genetics forums, part of the Horse Breeds, Breeding, and Genetics category
  • Is lethal white overo white syndrome codominance
  • Lethal white syndrome horse horses

Like Tree1Likes
  • 1 Post By Dreamcatcher Arabians

 
LinkBack Thread Tools
    01-07-2013, 07:48 PM
  #1
Foal
Lethal white syndrome

I have been assigned lethal white syndrome as a genetic research project for my Equine science class. Having been involved with horses for many years I was surprised that I have never heard of this before. I have started researching the topic and am absolutely shocked with the results. I can not believe I have never heard of this genetic disorder before! I have a few unanswered questions that I was hoping to get help with.
1. What is the genetic makeup of the foal with lethal white?
2. What is being affected genetically and physically?
3. Does it work under codominance or complete?
4. Is it plieotrophic?
Any information over lethal white syndrome will be greatly appreciated!
     
Sponsored Links
Advertisement
 
    01-07-2013, 08:07 PM
  #2
Trained
Quote:
Originally Posted by daisymay    
I have been assigned lethal white syndrome as a genetic research project for my Equine science class. Having been involved with horses for many years I was surprised that I have never heard of this before. I have started researching the topic and am absolutely shocked with the results. I can not believe I have never heard of this genetic disorder before! I have a few unanswered questions that I was hoping to get help with.
1. What is the genetic makeup of the foal with lethal white?
2. What is being affected genetically and physically?
3. Does it work under codominance or complete?
4. Is it plieotrophic?
Any information over lethal white syndrome will be greatly appreciated!
1. The foal will be homozygous for the frame overo allele (OO), they will not be affected if only heterozygous (nO) but will then be a carrier.

2. This allele causes improper intestinal development, aganglionosis of the bowel. Thus the foal will die within 72 hrs, if not euthanized prior. It also causes the lack of pigment in the coat.

3. See answer 1, it is recessive and requires 2 copies

4. Yes, the frame overo allele affects both coat color and the lack of intestinal development

From a paper on OLWS at K State:

What is OLWS?

This is a condition where a foal has inherited a recessive gene from both parents that encodes for a mutated protein located on some cells. The protein directly influences cells developing into color (pigment) and nerve cells. What this means is that OLWS foals are white (non-pigmented) and do not have normal nerve cells signaling to the intestines, because of the altered protein receptor. Ultimately, the result is a foal with little to no coat coloration (mostly or completely white) and cannot process milk, resulting in colic.

Here's a link to the entire paper, it should answer your questions pretty thoroughly.

College of Veterinary Medicine Veterinary Health Center
     
    01-07-2013, 08:17 PM
  #3
Trained
I just wanted to throw a spanner in the works here, if I may. LWO is a "fun" gene in that the "lethal" part is recessive, but the colour part is dominant. So for a lethal white foal to occur you need two copies, but the colour will display with just one.
     
    01-07-2013, 09:36 PM
  #4
Trained
Quote:
Originally Posted by Chiilaa    
I just wanted to throw a spanner in the works here, if I may. LWO is a "fun" gene in that the "lethal" part is recessive, but the colour part is dominant. So for a lethal white foal to occur you need two copies, but the colour will display with just one.
You're right, I zeroed in on the Lethal portion and forgot to metion the color portion.
Chiilaa likes this.
     
    01-07-2013, 10:04 PM
  #5
Foal
Thank you!! You helped me greatly!
     

Quick Reply
Please help keep the Horse Forum enjoyable by reporting rude posts.
Message:
Options

Register Now

In order to be able to post messages on the The Horse Forum forums, you must first register.

Already have a Horse Forum account?
Members are allowed only one account per person at the Horse Forum, so if you've made an account here in the past you'll need to continue using that account. Please do not create a new account or you may lose access to the Horse Forum. If you need help recovering your existing account, please Contact Us. We'll be glad to help!

New to the Horse Forum?
Please choose a username you will be satisfied with using for the duration of your membership at the Horse Forum. We do not change members' usernames upon request because that would make it difficult for everyone to keep track of who is who on the forum. For that reason, please do not incorporate your horse's name into your username so that you are not stuck with a username related to a horse you may no longer have some day, or use any other username you may no longer identify with or care for in the future.

User Name:
Password
Please enter a password for your user account. Note that passwords are case-sensitive.
Password:
Confirm Password:
Email Address
Please enter a valid email address for yourself.
Email Address:

Log-in

Human Verification

In order to verify that you are a human and not a spam bot, please enter the answer into the following box below based on the instructions contained in the graphic.


Old Thread Warning
This thread is more than 90 days old. When a thread is this old, it is often better to start a new thread rather than post to it. However, If you feel you have something of value to add to this particular thread, you can do so by checking the box below before submitting your post.

Thread Tools

Similar Threads
Thread Thread Starter Forum Replies Last Post
Lethal White? SarahAnn Horse Health 8 12-09-2011 08:42 AM
What is lethal white? Day Mares Horse Colors and Genetics 34 09-22-2011 08:43 PM
would this breeding cause a lethal white?? sumatimgrl Horse Breeding 15 03-17-2011 08:29 AM
Is Lethal White Syndrome the same as albino? Jessabel Horse Breeding 16 05-09-2009 10:15 PM
LETHAL WHITE FOAL SYNDROME - INFORMATION sparky Horse Health 4 01-11-2007 11:25 PM



All times are GMT -4. The time now is 12:17 AM.


Powered by vBulletin® Version 3.8.5
Copyright ©2000 - 2014, Jelsoft Enterprises Ltd.
Search Engine Friendly URLs by vBSEO 3.6.0