Now this is weird...

CheyAut · 12-07-2010, 11:01 AM

No, it's not always due to chimerism. And brindle in dogs is a gene, not due to chimerism. And what about calicos?

QHDragon · 12-07-2010, 11:15 AM

Sorry, it was from on of the threads linked in here:

Quote:

Originally Posted by Chiilaa

Interestingly, chimerism is also thought to account for male tortishell (calico) cats. Usually they are only female, since the colour genes are gender related, but rarely a male one will crop up. Most male tortishells are explained by people not recognising the colour correctly, or moles on the skin that can cause a similar pattern.

MN Tigerstripes · 12-07-2010, 11:58 AM

I was under the impression that male calicos are generally caused by them having more than one X chromosome. Their genotype is XXY, I believe it's called Klienfelters syndrome. They are generally sterile....

http://www.ncbi.nlm.nih.gov/pubmed/1163864

QHDragon · 12-07-2010, 12:23 PM

Wow, who knew that genetics could be so complicated! That's interesting that male calicos have carry XXY and are sterile.

Chiilaa · 12-08-2010, 01:57 AM

Quote:

Originally Posted by MN Tigerstripes

I was under the impression that male calicos are generally caused by them having more than one X chromosome. Their genotype is XXY, I believe it's called Klienfelters syndrome. They are generally sterile....

An animal model for the XXY Klinefelter's syndrome... [Am J Vet Res. 1975] - PubMed result

The ones that are genuinely tortishell (calico) are either chimera or Kleinfelters, yes.

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