Originally Posted by goneriding
I've heard of lethal white but was not aware it is directly connected to frames. It's interesting and odd at the same time that a coat pattern can be deadly.....
Lethal white isn't merely connected to frame. It is
frame. All frame horses only carry one of the frame markers, if a horse carries two of the markers it is homozygous for frame. While homozygous may be something great in tobianos, duns, blacks, etc. In the frame gene a homozygous factor is a guarantee of lethal white. If a foal receives a frame gene from both father and mother it will have lethal white, and die, every single time.