If only they could talk indeed...
If there is nothing physically wrong with her and she just has strong heats, as Saddlebags suggested, then a visit with the vet will at least rule stuff out. So it's worth doing as a first step when you have serious behaviour problems.
It just seems to be, from what I can gather reading your posts, that she is very unhappy. A horse who runs backwards, without much of a care about what it runs into, is a horse who is so desperate to get away from something that it has little regard for its own safety. Horses usually don't do things for no reason. It can just be a bugger figuring out what the reason is and sometimes you might not always like the answer.
Talk to your vet, but many years ago I asked my vet about Regumate and he did not recommend using it, on the grounds that it's nasty, toxic stuff that must be handled by humans, especially women, very carefully, and he was of the opinion that management and training changes would deal with heat-related acting out just as well, if not better.