Answers to questions asked.
1. Does she have bad ground manners? In my opinion, No. She is very respectful when being handled. Follows you like a dog without any hands on the lead rope. She will stand ground tied for an unlimited amount of time. She will stand while being saddled (Ground tied or someone holding her). She responds to all cues when being ridden or worked on the ground (Lunging).
2. Does she act "Freaky" when more than one person handles her? Myself I have tried to give shots and have had the same problems when two people handle her.
3. Is she scared of needles? I don't know... I would guess so. You can approach her with a needle showing, but once you start to try to insert the needle to medicate, she FREAKS!
Even if she behaves for everything else, the issues with giving shots can and probably are still very much a respect issue. Add in that you are making motions that aren't common/daily parts of the routine and that culminate in a stick and between those two things you've got a mess.
My mare would behave in all other ways on the ground, but when you brought out a needle she went bonkers. She did not respect that even in this instance she had to behave. Basically when push came to shove she felt that I wasn't a leader that would enforce my rules.
So I still believe that you should start out be working on desensitizing her to the pinch/poke and training her to stand for it.