The way I was always taught, which works best with my mare it seems, is to take a small water bottle and put a small amount of warm water in the bottom, then drop in the pills and swish around til they dissolve. Then use as a top dressing over the grain. Works like a charm with my girl.
Some others I've seen mix the pills in applesauce and feed them with the grain. What are YOUR special "spoon full of sugar" tricks?