Is my horse depressed? or could it be lymes disease?

So we started my 7yr old tb rocket on the clinton anderson method and after a few weeks he started showing showing signs of stiffness. So we had the vet come out and he discovered some arthritis in his hocks. And stifles. So we put him on cosequin asu and previcox. He hasn't shown much improvement and along with the stiffness he is very withdrawn, where he used to be very people oriented now when I approach him he doesn't want anything to do with me. We've tried getting him back into work because its been a month and he will not go anywhere and seems very sad or lathargic (spelling?)
Im at a loss I don't want him to be in pain or depressed I just don't know what else to do for him. He seems very unhappy
Could he be jealous because i've been working with my 2yr old a whole lot since he's was on rest.
Or lymes disease?

Your best bet is probably to have a vet come check him out, get a routine physical, and draw some blood. Better safe than sorry. :(
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It's not possible for him to be jealous or depressed, get your vet back as there is something else going on with him.

I am going to have the vet do blood work. Just was curious of others thoughts

I know dogs can get depressed, I don't see why horses can't also. They exhibit most other emotions.
But in your case I would suspect drug side affects first

Look at the logic,,,, horse was this way, I changed this (added drugs) now horse is this way, I would highly suspect it is the thing you changed or added right before the behavior change.

My first thought was to ask if you had him vet cleared for work again. If he is still in pain while working, he will associate that with you coming to get him from his pasture, and not want to come to you.

I second HowClever - call the vet out. Any change in a horse's personality like that should warrant a vet check.

Or, he's had a month off and has decided he wants another month off.

Just to so you all know, he was cleared by the vet to be ridden.
He started this behavior before we started him on any meds.
He has been lathargic, and very withdrawn from human contact since, and he used to be very people oriented. And very unwilling to do any type of work.

I have seen no improvements since he's been on the meds for over a month now. So that's Why I am thinking lymes because we should have seen some type of improvement by now. Also lymes is big in Maryland and I've pulled tons of ticks off of him this summer.

Blood tests are in order I would think.

If horse looks depressed something is wrong. I'd say do the blood tests (may be use another vet).

I'd think Lyme disease should be quite noticeable (they have problems moving around, at least those several horses I've seen diagnosed with it (I'm in MD as well BTW)). Does he move freely? Is he loosing the weight?