Pentosan IM Joint Injections
 
 

       The Horse Forum > Keeping and Caring for Horses > Horse Health

Pentosan IM Joint Injections

This is a discussion on Pentosan IM Joint Injections within the Horse Health forums, part of the Keeping and Caring for Horses category
  • Pentosan horse injections
  • How to give pentasan to a hors

Like Tree3Likes

 
LinkBack Thread Tools
    10-11-2012, 10:30 AM
  #1
Trained
Pentosan IM Joint Injections

My vet and I had discussed putting Rumor on Adequan due to her illness/injury. Then she called and discussed Pentosan with me and really feels like its the better way to go due to its great anti-inflammitory response. I trust her and have had her order it and we will start the injections soon. Its fairly new to the United States, but has been used widely in Australia, Europe and other over seas countries.

Does anyone have experience using it? Know people that use it?

We will be dosing Rumor with 1 shot per week, then once a month after. After 6 months, we will switch to Aqeduan if needed. She's also on oral Corti-Flex.
Posted via Mobile Device
     
Sponsored Links
Advertisement
 
    10-11-2012, 01:00 PM
  #2
Trained
I've never used Pentosan (I am a huge Adequan fan though) but after a bit of research it appears to be a well proven product, and a fraction of the price of Adequan.
I would be cautious with the 6mL dose all in one site, I would be tempted to re adjust the needle partway through the injection to reduce infection risk associated with a >5mL IM injection, but talk to your vet.
I'm also cautious on any claims on anything being effective once monthly. Adequan is not effective once monthly, it must be injected at least every 4 days, per manufacturers instructions. Pentosan claiming to be effective once monthly to me sounds sketchy.

Finally the last skeptical thing I'm going to say - it appears that Pentosan also advises the use of oral glucosamine with its use. Studies have shown that horses are unable to digest and absorb oral glucosamine. Why a company would contradict science and suggest use of a specific brand name product (Coseqin) is weird to me. IMO scrap the oral supplement, its nothing more than expensive molasses. But talk to your vet.

Good luck and report back your findings!
Posted via Mobile Device
     
    10-11-2012, 01:27 PM
  #3
Trained
My vet wants me to do a loading dose of the Pentason for the first one or two injections. Then go down to the regular dose, and then once a month after the initial 4 doses. Ill see what doses my vet has me doing once I pick the shots up, and ill definitely document my results.

When I was looking into Adequan, they say to use it every 4 days for 7 treatments, and then drop down to once a month.

I have had success with one specific oral joint supplement called Regenex. It has 5000ml gluclosamine, and 5000ml msm, plus 1000ml of chondriotin. Horses are large animals and they need high doses in order to see an effect. If people and other animals have success talking orals, why wouldnt an equine? It just has to be the right dose is my thinking. Then again, im not a vet.

I would like to not have to give oral joint meds though because I do not grain every single day. So im really hoping that IM shots is the way to go.

Can I ask why there is the risk on infection with putting the 6ml all into one site? Im even thinking I may have 10ml-12ml to inject depending on what my loading dose is. I was having to give 30ml penicillin (broken into 2 15ml shots) twice a day, and 30ml gentamicin all into one site. So the measley 6ml doesnt seem like much to me compared to the antibiotics Rumor was on.
Posted via Mobile Device
     
    10-11-2012, 02:09 PM
  #4
Trained
Quote:
Originally Posted by CLaPorte432    
My vet wants me to do a loading dose of the Pentason for the first one or two injections. Then go down to the regular dose, and then once a month after the initial 4 doses. Ill see what doses my vet has me doing once I pick the shots up, and ill definitely document my results.

When I was looking into Adequan, they say to use it every 4 days for 7 treatments, and then drop down to once a month.

I have had success with one specific oral joint supplement called Regenex. It has 5000ml gluclosamine, and 5000ml msm, plus 1000ml of chondriotin. Horses are large animals and they need high doses in order to see an effect. If people and other animals have success talking orals, why wouldnt an equine? It just has to be the right dose is my thinking. Then again, im not a vet.

I would like to not have to give oral joint meds though because I do not grain every single day. So im really hoping that IM shots is the way to go.

Can I ask why there is the risk on infection with putting the 6ml all into one site? Im even thinking I may have 10ml-12ml to inject depending on what my loading dose is. I was having to give 30ml penicillin (broken into 2 15ml shots) twice a day, and 30ml gentamicin all into one site. So the measley 6ml doesnt seem like much to me compared to the antibiotics Rumor was on.
Posted via Mobile Device

Glucosamine and Chondroitin molecules are actually too large to absorbed through the horse's digestive tract. You probably were seeing results from the MSM. Humans and horses digest foods in completely different ways so no, oral supplements do not affect horses the same way they do humans. Yes glucosamine is beneficial to horses, but only when given in a way that they can absorb it, this is to say IM. My vet has told me that he feels bad the clinic he runs out of sells these oral supplements at the front desk but that if people are dumb enough to spend hundreds of dollars on that stuff, it's money. He has never recommended an oral supplement for any of my horses suffering from joint disease either degenerative or acute. Always IM IV or IA.

Adequan does not recommend monthly use of their product, it is right in their FAQ at To get the maximum benefit use Adequan I.m. 1/4/7
I quote "Once a month dosing is not clinically proven to be effective."

I can't find the article right now, but to reduce the risk of a Clostridial Myonecrosis (CM) infection (google it) the dose should not be larger than 5mL. That is one of the risk factors of the infection (injecting large volumes). When administering antibiotics I have always been advised by my veterinarian to split the doses into multiple injection areas.
6mL might be pushing it, but 10-12mL is begging for complications. Antibiotics are not as much of an issue I don't think, but I would definitely be splitting a loading dose up. As well I haven't seen the need for 2x the volume for a loading dose in any joint treatments. Pentosan seems very clear with the dosage requirements:
Administer at a dose rate of 3 mg/kg body weight (1.5 g / 500 kg horse), by intramuscular injection, at 5 – 7 day intervals for four injections.

But anyways, good luck!
EvilHorseOfDoom likes this.
     
    10-11-2012, 02:15 PM
  #5
Trained
Thank you Anabel! As ever, you are very insightful and full of great information.
Posted via Mobile Device
     
    10-11-2012, 02:26 PM
  #6
Trained
Quote:
Originally Posted by CLaPorte432    
Thank you Anabel! As ever, you are very insightful and full of great information.
Posted via Mobile Device

Or just scarily used to shooting horses up with drugs haha who are we kidding?
You're welcome, I'm interested to hear how the Pentosan works. It would be nice to finally have a bit of a less expensive alternative to Adequan for OA support and cartilage repair!!
I will also be bugging my vet about this :P
     
    10-11-2012, 02:32 PM
  #7
Trained
Oh absolutely. My horse is recovering from a bacterial infection, developed into cellulitis, bacteria travelled into her big rocker joint in her hock. She's had 2 joint flushes. She is still quite swollen, a little sore due to the dilution of her joint fluid. So we are hoping the shots will rebuild the fluid, decrease the swelling and not break my bank anymore then it already has been. HaHaHa.

I will keep you informed of how the Pentosan works for her. My vet is excited to try it.
Posted via Mobile Device
     
    10-11-2012, 02:54 PM
  #8
Trained
Quote:
Originally Posted by CLaPorte432    
Oh absolutely. My horse is recovering from a bacterial infection, developed into cellulitis, bacteria travelled into her big rocker joint in her hock. She's had 2 joint flushes. She is still quite swollen, a little sore due to the dilution of her joint fluid. So we are hoping the shots will rebuild the fluid, decrease the swelling and not break my bank anymore then it already has been. HaHaHa.

I will keep you informed of how the Pentosan works for her. My vet is excited to try it.
Posted via Mobile Device
Yes, have you tried Legend IV yet?? I would also probably want to do a few shots of that. Being that she has had such an infection I would be wary of doing IA Legend, but that might also benefit her.

Good luck!! Yay vet bills (not)!!
     
    10-11-2012, 02:57 PM
  #9
Trained
No I have not tried the Legend IV. Ill have to research it and see what it does and if itd benefit her. It has been a very long 5 weeks. *sigh*
Posted via Mobile Device
     
    01-01-2013, 11:23 PM
  #10
Trained
Anabel, I wanted to update you on how Pentosan is working on my mare.

Its flat out...AMAZING! I am so happy with the results im seeing by using this injection. Rumor occassionaly has moderate swelling when she is due for another shot, within a day of giving her the injection, the swelling is very minimal, and she moves very fluidly.

A few weeks ago, she still had a slight hitch to her transition into the trot, now I don't notice any hitch at any gait.

She had muscle atrophy on her left hind hip due to the way she limped for so long, and now you can visibly see where she is rebuilding muscle tone to that hindend.

I also give MSM daily but my miracle drug has been the Pentosan. I highly recommend giving it a try. I pay $19 per 6ml shot. It was $38 for the 12ml loading doses.

To start we did 4 loading doses, once a week, because of the severity of my mares injury. And now I am giving one 6ml shot every 2 weeks.

3 months later...How lame is she? is a link to recent videos of her. Those were just a few weeks ago. Now, I don't see any hitch to her stride...

completely freaking out is a link to her entire injury, recovery and treatments. Lots of pictures if your interested in seeing her at her worst. It'll make you appreciate how well she is moving and looking now.
Posted via Mobile Device
pgboogie and EvilHorseOfDoom like this.
     

Thread Tools

Similar Threads
Thread Thread Starter Forum Replies Last Post
Has anyone used Legend? IV or Injections? waresbear Horse Health 10 06-14-2012 12:28 AM
Pentosan Polysulfate = DEATH?!! nucks93 Horse Health 18 03-30-2012 09:41 AM
Pentosan Question... Zimpatico Horse Health 1 07-19-2011 05:04 PM
I.M. Injections ~*~anebel~*~ Horse Health 3 06-28-2011 05:56 PM
Would you give joint injections to a 6yo reiner as a preventative measure? CloudsMystique Western Riding 19 03-09-2010 10:13 PM



All times are GMT -4. The time now is 03:04 PM.


Powered by vBulletin® Version 3.8.5
Copyright ©2000 - 2014, Jelsoft Enterprises Ltd.
Search Engine Friendly URLs by vBSEO 3.6.0