With various horses, I have done the legend IV and found it to have minimal results. Adequan given 6 doses every 4 days and then as recommended seemed to work well in conjunction with IA injections of legend/kenalog/amikacin. Then I switched to hylartin for joint injection and they lasted 6-12 months easily instead of the 3-6.
I just started a round of pentosan in 2 of mine. They will get 6mL every 6 days for 6-7 shots as a loading dose and then I will try a shot every 2-4 weeks depending on the results and the individual. I was super leery of pentosan when I heard about it early last year. My policy is not to use unapproved drugs, but I had several reputable friends tell me about how it worked for them. I decided to try it.
As for the risk of clostridium infection, that is present with ANY break of the skin. That is why you must practice aseptic techniques and monitor the injection site. 6mL is not a large shot and the pentosan itself is very viscous, much thinner than injecting penicillin for example. Neither of my horses had any issue. I will be rotating injection sites though.
I almost think I'm already seeing some improvement, but I'm trying not to say anything to see if other people notice what I *think* I see.
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