Usually just one ankle and occasionally both, they start to hurt after riding for a longer period of time. If I take my feet out of the stirrups they are fine, but as soon as they go back in it hurts.
This time my left ankle is still quite sore two days on.
I've never had any injuries in either ankle.
It seems to happen less in my stock saddle which has wider stirrups - i'm considering trying out some EZ Ride stirrups that are wide and also padded, on my wintec for when I ride Latte. I was in the wintec this weekend when it happened.