I am not a fan of synthetic saddles. I prefer the feel that decent leather develops. Haven't seen anything close to that in synthetic saddles.
They also don't seem to conform to the general riding position the way a leather saddle does. Finally, I've yet to see a well-made tree in synthetic saddles. And I'm a fan of LaPorte trees, which are carbon fiber mix.
My family has sent several to missionaries in central America, though, because leather rots right off the trees. They ride little burros to the remote areas. The locals often ride wood trees with burlap or some other coarse material wrapped and stuffed around them.
The synthetics are a hot item and often stolen if let out of a worke'rs sight. Unfortunately, I don't know anyone who can outfit a whole region with synthetic saddles all at once, so I guess they will continue one thief at a time!