Horse Motels International. Horse motel & overnight stabling directory for the traveling equestrian. We find horse motels, horse hotels, overnight stabling, overnight boarding, horse vacations, ranches, bed and breakfasts, and hurricane shelter. Horsetrip.com-An Online Overnight Stabling Directory for Horse Stabling and Horse Motels
Look at the places on either of these sites and find a couple along your route, and make plans to overnight at them.
There are many choices on them, from B&B's to stables that overnight for horses, to campgrounds. I searched for ones that were close to Interstate, easy to get to, and had good stalls, and was well satisfied with each one.
And dropped trailer at one place, as it had locking fence/gate around barn.
You should be able to travel about 10 hours or so, maybe little more if you factor in fueling, get to stable, unload, let horses rest and eat, and hit motel for yourselves.
I would not unload the horses anywhere else, as too much chance of something happening is my thought. Not much fun trying to load a horse when there is risk if it pulls loose, it will possibly run into traffic, and too many weirdos around usually too.
I trailered up from LA (Lower Alabama) to NW MO, right at 1000 miles, and overnighted 2 nights. Wanted to offload horses up here in daylight, so could see fences.
But making trip straight through is too hard on them and you too.