Also depends on why it has a salvage title. If it was wrecked, that's one set of problems. If it was invovled in a flood (often this is the case in newer, low mileage vehicles) it is whole 'nother set of issues and those you really don't want to deal with.
Basically you have to go into a salvage title situation with a couple things in mind. First is the thing is going to need more TLC then a vehicle of the same age/mileage that still has a clear title. Second, when you go to sell it you wont be able to get as much money for it. So, I guess third, keep one and two in mind when giving an offer. The vehicle most likely isn't worth what they are asking for it.