I had a vet give my geld a TON of an ace mixture because he needed his sheath cleaned BAD, and he wasnt reacting to it.
He had so much he was walking like a drunk. No side effects, but I probably would request derm or xylazine if its needed again. Now my colt just got gelded, so he's got a fair amount of sheath swelling. I wont give him ace for any reason right now, because combined with his swelling it could be an issue.