Canine Cushing Questions... - The Horse Forum
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post #1 of 5 Old 02-22-2011, 03:04 PM Thread Starter
Join Date: Nov 2010
Location: Pennington, NJ
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Unhappy Canine Cushing Questions...

I have a 9 1/2 year old Boston Terrier, Lucy. I adopted her almost 5 years ago when my last rescued Boston passed away from cancer. Lucy went completely blind at a year old from juvenile cataracts. At 4, her owners decided they just "didn't want to take care of her anymore" and took her to the vet to be euthanized. The vet refused, and offered to find her a new home instead. That's where I come in!

Anyway, she has rarely been sick in the time that I've had her, but did have an eye removed last year when she developed glaucoma in it and it was fluctuating in pressure, causing pain. When they did that surgery, they noticed her ALKP levels were high. The surgeon said I should have my vet check it again in a few months. Well, we went back in November to have her retested. 991 U/L. Normal range is 23-212. She showed no other symptoms at all, so the vet recommended Denamarin for two months, then retest. We had her retested last night. The vet called this morning and her level is now 1651 U/L. WTH?!?!? She is still showing no symptoms and acts like her usual self. The vet wants to see her tomorrow for a urinalysis and ACTH Simulation Test. If they are inconculsive, they will do an ultrasound of Lucy's liver.

Has anyone had any experience with this and / or cushings? Any other thoughts on what might be going on? If we are looking at cushings, what treatments have you used, and how positive were the results? I'd love any thoughts and stories...
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I've spent most of my life riding horses. The rest I've just wasted.
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post #2 of 5 Old 02-22-2011, 03:17 PM
Join Date: Dec 2009
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sorry this is a little off topic, but my step mum gave her boston away about 5 years ago and the bostons name was lucy. i wanted to keep her but she wasnt toilet trained and was always running away. lol thought it was a weird coincadence. anyways i hope all is well, im sorry ive never had any experience with cushions. the boston that we have is about 9 and knock on wood but is still going strong and is an awesome companion.
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post #3 of 5 Old 02-23-2011, 09:06 AM Thread Starter
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Bump... Anyone??

I've spent most of my life riding horses. The rest I've just wasted.
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post #4 of 5 Old 02-23-2011, 01:55 PM Thread Starter
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Well, Lucy went for her urinalysis and ACTH tests this morning... No results til tomorrow. Poor girl is NOT happy to be at the vet twice in one week!

I've spent most of my life riding horses. The rest I've just wasted.
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post #5 of 5 Old 02-23-2011, 02:47 PM
Join Date: Jul 2010
Location: Medazzaland
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I am an LVT so we see some animals with Cushings. My dog Aimee even had it. Usually dogs can live happy lives as long as you keep up with their treatment. Some doctors prescribe Lysodren and others trilostane. Lysodren can be tricky to dose right and can be dangerous so one of my vets prefers trilostane. If I were you I would research cushings so you'll be more comfortable with it. A quick summary is that either the pituitary gland or the adrenal gland is working overtime and producing more cortisol than needed so you get side effects such as pot belly, increased drinking and urination as well as hunger. Sometimes you don't notice anything until the liver values are up. With cushings there is usually in abnormality with the pituitary gland so the only option is medication. When its the pituitary gland, the gland doesn't realize there is enough cortisol in the body so it keeps telling the adrenal glands to make more. Sometimes its the adrenal glands that are the problem and they can potentially be removed but that doesn't usually take place. When its the adrenal glands causing the problem they just keep making more and more cortisol even though the pituitary gland is telling them that the body has enough.

I hope I helped!! Good luck with your baby! She's very cute!
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