Even though I know very little about nutrition and metabolism, I wouldn't actually agree that it's not about eating less (if you are in fact over eating) but I would never suggest anyone try eating too little.
Understand portion size, the different kinds of fats, carbs and sugars is very important. And understanding these things, I think would be very empowering.
To be learning as you go, always improving and evolving your ideas on healthy body and healthy mind I think would go a long way -and your research into neuro-science is definitely a good sign that you're apt at self education and enjoy it!
Maybe try adjusting one thing at a time? Maybe read up about sleep patterns effects on weight loss and the best time of day for exercise (there are different times where your body gets more out of the process than at others like, exercising at night before bed is a little like flogging a dead horse. It might make you feel better but in the long run counts for very little) and then set a goal with your new found knowledge like 'Ok so this first week, I'm going to focus on getting my energy levels up so I'm going to be in bed by 10.30pm and rise early for a short walk'.
ALL OF THIS BEING SAID: I am also over weight, so I really shouldn't be trying to give advice to anyone. But if you do decide to do this, I'd love if we could have a little journal type thread where people could post up things like :
Today I ate: <Insert food here>
Today I: <Insert exercise here>
Total Weight Loss to date: 0.1lbs (I completely don't understand pounds so I have no idea if that number means anything hehehe)
Comments: <Thoughts on if they're starting to have more energy/diet is making them lethargic and thus wouldn't recommend it etc.>
Even though I could see that this may make some people uncomfortable posting their results up, but it might prove to be a good inspiration/educational to other members and give the poster something to look forward to to tell people their progress and what does/does not work.
Now I'm rambling, my apologies!