The Cohutta wilderness area combined with the Big Frog Wilderness area makes up the largest wilderness east of the Mississippi river. While the mountains are not nearly as high as out west, they are steep.
My wife and I ride a lot in the rugged southern Appalachian mountains and on one occasion we had a tree that was across the trail and cliffs on both sides.
A 12 mile ride turned into a 22 mile ride, as we rode the same way out rather than making the loop and we got back right at dark.
We take small hand saws, but this tree was huge.
Every time we ride in the wilderness, we take enough equipment to be comfortable should we need to spend the night.
So, yes, it can happen, and in fact, has happened to me.
For we wrestle not against flesh and blood, but against principalities, against powers, against the rulers of the darkness of this world, against spiritual wickedness in high places.