Epm???? - Page 3 - The Horse Forum
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post #21 of 54 Old 13-11-2009, 06:39 PM Thread Starter
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Yeah I was a little myphed on the "borderline" part also.

Be wary of the horse with a sense of humour. - Pam Brown
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post #22 of 54 Old 13-11-2009, 07:50 PM
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when my gelding was tested the vet told me: low grade positive. did that mean he was exposed but the chances are low he had it?? I never really asked because we had already decided to put him down t that point. Selenium is great, but its toxic if fed too much.
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post #23 of 54 Old 13-11-2009, 09:25 PM
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It's likely that "low grade positive" was used to describe a weak positive on the WB test, which would indicate that he had antibodies to S. neurona circulating in the blood but not a high number of them. That would likely indicate that exposure occured sometime in the past.

Cindy D.
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Last edited by Ryle; 13-11-2009 at 09:28 PM.
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post #24 of 54 Old 13-11-2009, 09:52 PM
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we had him tested for epm at 5 and at 8.
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post #25 of 54 Old 14-11-2009, 02:45 AM
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I like to use Baycox 5% twice a week until I get the EPM under control. I buy the Toltrazuril powder from Stop EPM with Baycox & Toltrazuril and just put it on the horses food. Once you get about two weeks worth of treatments into them you notice a huge difference in there gait. I highly recommend this treatment because it's much cheaper than marquis and more effective in my opinion.
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post #26 of 54 Old 14-11-2009, 09:22 AM
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Quote:
Originally Posted by DaysofThunder View Post
I like to use Baycox 5% twice a week until I get the EPM under control. I buy the Toltrazuril powder from Stop EPM with Baycox & Toltrazuril and just put it on the horses food. Once you get about two weeks worth of treatments into them you notice a huge difference in there gait. I highly recommend this treatment because it's much cheaper than marquis and more effective in my opinion.
ive never seen the tolrazuril powder. ill have to keep a link to that!!
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post #27 of 54 Old 15-11-2009, 09:19 AM
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Originally Posted by sillybunny11486 View Post
we had him tested for epm at 5 and at 8.
Ok, I'm really not sure what you mean by this....5 o'clock and 8 o'clock? 5 days and 8 days?

You don't diagnose EPM by testing twice on blood a certain length of time apart.

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post #28 of 54 Old 15-11-2009, 09:27 AM
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Quote:
Originally Posted by DaysofThunder View Post
I like to use Baycox 5% twice a week until I get the EPM under control. I buy the Toltrazuril powder from Stop EPM with Baycox & Toltrazuril and just put it on the horses food. Once you get about two weeks worth of treatments into them you notice a huge difference in there gait. I highly recommend this treatment because it's much cheaper than marquis and more effective in my opinion.
This treatment is no more effective than Marquis because toltrazuril is the parent drug of ponazuril (Marquis). The body turns toltrazuril into ponazuril and thus treatment of EPM occurs if dosed correctly. However, as there are FDA approved drugs for the treatment of EPM and Baycox is not one of them most vets do not use this product because there are not as many studies on it's correct dosing. It also can lead to a vet being fined for prescribing a non-proven drug for treatment of a disease when their are approved drugs available.

Cindy D.
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post #29 of 54 Old 15-11-2009, 04:20 PM
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Originally Posted by Ryle View Post
This treatment is no more effective than Marquis because toltrazuril is the parent drug of ponazuril (Marquis). The body turns toltrazuril into ponazuril and thus treatment of EPM occurs if dosed correctly. However, as there are FDA approved drugs for the treatment of EPM and Baycox is not one of them most vets do not use this product because there are not as many studies on it's correct dosing. It also can lead to a vet being fined for prescribing a non-proven drug for treatment of a disease when their are approved drugs available.
How is "Baycox" not proven? It was the first thing out that was used for treatment of EPM. Marquis is nothing more than a bunch of hype. We have used marquis and seen absolutely no good results and for the money is costs it's definitly not worth the time or the headache. If you use the Toltrazuril Powder every five days you see great results. I like the powder because you don't have to have a vet run the nasogastric tube to give it. The biggest reason the vets like Marquis is they make a lot more $$$$$ selling it.
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post #30 of 54 Old 15-11-2009, 06:22 PM
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How is "Baycox" not proven? It was the first thing out that was used for treatment of EPM. Marquis is nothing more than a bunch of hype. We have used marquis and seen absolutely no good results and for the money is costs it's definitly not worth the time or the headache. If you use the Toltrazuril Powder every five days you see great results. I like the powder because you don't have to have a vet run the nasogastric tube to give it. The biggest reason the vets like Marquis is they make a lot more $$$$$ selling it.
Truthfully, I question the quality of diagnosis you are basing results on. Unfortunately EPM was WAY over diagnosed for years....and still is to some extent though more vets know what constitutes appropriate diagnostic protocols now. Lots of horses who are diagnosed with EPM don't have EPM....I know several cases where this is what occured.
The fact that you expect a horse's gait to be improved in 2 weeks time is proof that you don't really understand the treatment of the disease because ponazuril (what toltrazuril is turned into by the body) requires 2 weeks treatment to get up to a steady lethal dose for the parasites in the central nervous system. That is the point where it really starts effecting a good kill of the parasites, but that doesn't mean that it's going to make your horse better in 2 weeks time because when the parasites die they emit toxins that cause inflammation in the central nervous system and often leads to a worsening of symptoms.

Baycox has never been an FDA approved treatment for EPM. It has been used off-label for many years without sufficient studies to prove effectiveness, required dosing, etc. Marquis was the first PROVEN effective treatment marketed.

So your vets run a nasogastric tube to give Marquis?

In carefully controlled studies over several years Marquis has been proven effective at treating EPM. I know many many owners who have successfully used Marquis to treat their horses. And again, the toltrazuril you are recommended is turned into pontazuril (the active ingredient in Marquis) by the body....so if Marquis didn't work toltrazuril wouldn't work.

Cindy D.
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