Equioxx - The Horse Forum
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post #1 of 31 Old 12-03-2019, 01:58 PM Thread Starter
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Equioxx

Some people say to give equioxx 3 days out from the show with the 3 pills the first day and then 1 the following. Others say to give the loading dose a week before a show and one pill each day after. I'm runnign saturday so would it even make a difference if I started it today?
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post #2 of 31 Old 12-03-2019, 03:02 PM
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Following as my horse is on the same medication but the vet told me to only give one pill a day, every day. Never heard of increasing the dosage so I'm curious.
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post #3 of 31 Old 12-03-2019, 06:01 PM
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I have also never heard of giving a horse more than 57 mg daily. That’s from the lameness facility I have used and from the other two vet facilities I use..

If people are drugging their horses to the degree you describe, they are asking for trouble in a lot of ways —- the horse possibly going down with them for starters.

Why on earth would someone think it’s ok to shove that much pain killer into a horse, to get to a show?

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post #4 of 31 Old 12-03-2019, 07:45 PM
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This is one case I found online - however it is an accidental overdose of 30X the normal dose. Still, it outlines where problems might occur if you increase the dosage. I assume this is not on a vet's advice... that alone would make me walk away.

https://thehorse.com/112380/problems...icox-overdose/

And from the manufacturer (you're planning on giving 3 pills a day for several days, so roughly 1.5 mg/kg a day. See bolded list of side-effects below. Mind you, they gave the higher dose for a much longer period than you're talking about, but still, I would not take the risk.

Horses
With a dose of 0.3 to 0.5 mg/kg a day for 30 days:{R-5; 11}
Ulcers, oral, increased incidence of
With a dose of 0.1 to 0.5 mg/kg a day for 42 days:{R-5; 11}
Blood urea nitrogen (BUN) and/or creatinine, mildly elevated—
with 0.5 mg/kg; buccal mucosal bleeding time (BMBT),
prolonged—with 0.5 mg/kg; papillary necrosis and/or
tubulointerstitial nephropathy—with 0.3 to 0.5 mg/kg; ulcers,
oral, delayed healing of or increased incidence of
Note: One horse with an elevated BUN and/or creatinine and
prolonged BMBT had a dilated pelvis of the right kidney,
one had bilateral tubulointerstitial nephropathy and bilateral
papillary necrosis, and a third had no gross changes seen at
necropsy.
With a dose of 0.25 to 1.25 mg/kg a day for 92 days:{R-5; 11}
Erosions of the skin of the mandible and head—with 0.25 to
1.25 mg/kg; hepatic enzymes, elevated, including alanine
aminotransferase (ALT), aspartate aminotransferase (AST),
gamma-glutamyltransferase (GGT), and sorbital dehydrogenase
(SDH)—with 1.25 mg/kg; papillary necrosis and/or
tubulointerstitial nephropathy; renal hemorrhage and
nephropathy (urine GGT and protein levels increased)—with 0.25
mg/kg; ulcers, gastric, increased incidence of—with 0.25 to 0.75
© 2007 The United States Pharmacopeial Convention All rights reserved 4
mg/kg; ulcers of the lips, gingiva, and tongue—with 0.25 to 1.25
mg/kg

Note: Six horses administered 1.25 mg/kg a day in the safety
study summarized above were monitored for about 56 days
after treatment. Partial to full resolution of oral and skin
ulcers occurred, but no recovery from tubulointerstitial
nephropathy was seen.
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post #5 of 31 Old 12-03-2019, 08:27 PM
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I know a lot of people give it for larger shows that last 4-5 days. I don't know what the dosages are though.

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post #6 of 31 Old 12-04-2019, 01:26 AM
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Of course, you know my thoughts on the Equioxx, OP. But to share with everyone else on the discussion on the thread.

The two lameness vets that I use (one is a regional specialist) have instructed me to give three 57 mg tablets of Equioxx on the first day (loading dose) and then one 57 mg tablet each day thereafter. Equioxx is not like bute; it does need to reach a therapeutic level in the system in order to deliver the best results. You don't have to do the loading dose, but it will get you to that therapeutic level faster. I also try to give it roughly the same time every day; again, to be as consistent as I can with the dosage. If for some reason they end up being off it for a couple weeks (maybe if I was out of town for an extended period, or they had a lameness exam where they needed to be off it, etc), I will restart with the loading dose again when I start giving it again. But if it's only a couple days that they miss it, I won't repeat the loading dose because they should still have enough of the medication in their system to get back to that therapeutic level fairly quickly.

So that is what I do with my horses because that is what my vets have instructed me. Red has been on it for years to help manage his heel pain. However, I only give it during the competition season and not during the winter. Dexter got put on it this year due to navicular changes in his front feet ..... and I suspect he'll get to continue to be on it now that he went and damaged his hock (time will tell).

I notice a difference in my horses after they have been on it about ONE WEEK, and that is with doing the loading dose. So for me, it makes zero sense to give it 3 days away from an event because I don't feel it's giving the horse the benefit it needs. But that's my opinion and what I have experienced. If it is in the horse's best interest to be on Equioxx, for whatever the reason may be, great. But I don't really see a need for ONLY giving it during a big weekend for a large show. If the horse is sound otherwise..... why do they need it for a big show?

Of course, any medication has the potential to have side effects and you should always consult with your vet for your specific horse. But that is what I do for my horses.

There have been studies on this type of medication, that compared doing a loading dose to not doing a loading dose. Again, the loading dose just gets you to the therapeutic level quicker. Yes, the label for Equioxx also says you aren't supposed to use it long-term, but of course there are plenty of vets that prescribe it that way and plenty of horses that get it that way.
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post #7 of 31 Old 12-04-2019, 09:12 AM Thread Starter
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Quote:
Originally Posted by Acadianartist View Post
This is one case I found online - however it is an accidental overdose of 30X the normal dose. Still, it outlines where problems might occur if you increase the dosage. I assume this is not on a vet's advice... that alone would make me walk away.

https://thehorse.com/112380/problems...icox-overdose/

And from the manufacturer (you're planning on giving 3 pills a day for several days, so roughly 1.5 mg/kg a day. See bolded list of side-effects below. Mind you, they gave the higher dose for a much longer period than you're talking about, but still, I would not take the risk.

Horses
With a dose of 0.3 to 0.5 mg/kg a day for 30 days:{R-5; 11}
Ulcers, oral, increased incidence of
With a dose of 0.1 to 0.5 mg/kg a day for 42 days:{R-5; 11}
Blood urea nitrogen (BUN) and/or creatinine, mildly elevated—
with 0.5 mg/kg; buccal mucosal bleeding time (BMBT),
prolonged—with 0.5 mg/kg; papillary necrosis and/or
tubulointerstitial nephropathy—with 0.3 to 0.5 mg/kg; ulcers,
oral, delayed healing of or increased incidence of
Note: One horse with an elevated BUN and/or creatinine and
prolonged BMBT had a dilated pelvis of the right kidney,
one had bilateral tubulointerstitial nephropathy and bilateral
papillary necrosis, and a third had no gross changes seen at
necropsy.
With a dose of 0.25 to 1.25 mg/kg a day for 92 days:{R-5; 11}
Erosions of the skin of the mandible and head—with 0.25 to
1.25 mg/kg; hepatic enzymes, elevated, including alanine
aminotransferase (ALT), aspartate aminotransferase (AST),
gamma-glutamyltransferase (GGT), and sorbital dehydrogenase
(SDH)—with 1.25 mg/kg; papillary necrosis and/or
tubulointerstitial nephropathy; renal hemorrhage and
nephropathy (urine GGT and protein levels increased)—with 0.25
mg/kg; ulcers, gastric, increased incidence of—with 0.25 to 0.75
© 2007 The United States Pharmacopeial Convention All rights reserved 4
mg/kg; ulcers of the lips, gingiva, and tongue—with 0.25 to 1.25
mg/kg

Note: Six horses administered 1.25 mg/kg a day in the safety
study summarized above were monitored for about 56 days
after treatment. Partial to full resolution of oral and skin
ulcers occurred, but no recovery from tubulointerstitial
nephropathy was seen.
I think you misunderstood me, I was referring to doing the loading dose (3 pills) on the third day out from the show, and then one pill for the remaining days. The vet advised me to do it three days before, but I know some people say they don't see a difference until a week of the horse being on it.
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post #8 of 31 Old 12-04-2019, 09:22 AM Thread Starter
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Quote:
Originally Posted by beau159 View Post
Of course, you know my thoughts on the Equioxx, OP. But to share with everyone else on the discussion on the thread.

The two lameness vets that I use (one is a regional specialist) have instructed me to give three 57 mg tablets of Equioxx on the first day (loading dose) and then one 57 mg tablet each day thereafter. Equioxx is not like bute; it does need to reach a therapeutic level in the system in order to deliver the best results. You don't have to do the loading dose, but it will get you to that therapeutic level faster. I also try to give it roughly the same time every day; again, to be as consistent as I can with the dosage. If for some reason they end up being off it for a couple weeks (maybe if I was out of town for an extended period, or they had a lameness exam where they needed to be off it, etc), I will restart with the loading dose again when I start giving it again. But if it's only a couple days that they miss it, I won't repeat the loading dose because they should still have enough of the medication in their system to get back to that therapeutic level fairly quickly.

So that is what I do with my horses because that is what my vets have instructed me. Red has been on it for years to help manage his heel pain. However, I only give it during the competition season and not during the winter. Dexter got put on it this year due to navicular changes in his front feet ..... and I suspect he'll get to continue to be on it now that he went and damaged his hock (time will tell).

I notice a difference in my horses after they have been on it about ONE WEEK, and that is with doing the loading dose. So for me, it makes zero sense to give it 3 days away from an event because I don't feel it's giving the horse the benefit it needs. But that's my opinion and what I have experienced. If it is in the horse's best interest to be on Equioxx, for whatever the reason may be, great. But I don't really see a need for ONLY giving it during a big weekend for a large show. If the horse is sound otherwise..... why do they need it for a big show?

Of course, any medication has the potential to have side effects and you should always consult with your vet for your specific horse. But that is what I do for my horses.

There have been studies on this type of medication, that compared doing a loading dose to not doing a loading dose. Again, the loading dose just gets you to the therapeutic level quicker. Yes, the label for Equioxx also says you aren't supposed to use it long-term, but of course there are plenty of vets that prescribe it that way and plenty of horses that get it that way.
I asked for it when I went to the vet since I saw results from my friend using it for her horse. She gives it three days out from a show as well. This is dangerous to say on this site since most people on here are anti-injections, but as you know, my horse in injected which is probably why the vet didn't recommend equioxx. I just asked for it and they said I could use it if I wanted to. They both recommended doing it 3 days out, but only one said do the loading dose. The reason I wanted to use it was just in case he was having any general aches and pains.
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post #9 of 31 Old 12-04-2019, 09:24 AM Thread Starter
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Quote:
Originally Posted by walkinthewalk View Post
I have also never heard of giving a horse more than 57 mg daily. That’s from the lameness facility I have used and from the other two vet facilities I use..

If people are drugging their horses to the degree you describe, they are asking for trouble in a lot of ways —- the horse possibly going down with them for starters.

Why on earth would someone think it’s ok to shove that much pain killer into a horse, to get to a show?
I didn't think the loading dose and then one pill a day after was a lot, but I guess we all have different opinions.
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post #10 of 31 Old 12-04-2019, 09:29 AM
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Never heard of such sporadic use of Equioxx. My Navicular mare was on it for a couple of years and received it daily. Then we switched to Opshos shots.

You need to be careful with giving medication not at the vet recommended dosage. You can also go do the manufacturers website and read dosage instructions. Equioxx is not like bute - it is meant to be given long term and not just when competing or showing.
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