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When relying on fecal samples as indicators of parasites then remember that they don't show results for tapeworms, bots or encysted small strongyles (Cyathostomes) and they are probably the most dangerous and debilitating of the parasites.
ENCYSTED STRONGYLES – SMALL WORMS, BIG PROBLEMS – Vet Services Hawke's Bay (vshb.co.nz)

There is a saliva test for tapeworm and it is now available in the US
Targeting Tapeworm Treatment Using EquiSal Tapeworm Saliva Testing - EquiManagement

The resistance to dewormers is a direct result of owners using daily deworming methods and even a monthly system, using the same active ingredient each week.

Deworming twice a year, using a targeted active - for example, Moxidectin for encysted strongyles and Praziquantel for tapeworms and bots - is unlikely to create a resistance but it will protect your horse from potentially life threatening parasites

Combine that with good pasture management and careful attention to removing bot eggs and you can reduce problems by a lot

Unfortunately, tapeworm are spread to the horse by pasture mites that the horse ingests while grazing
 
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